PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer’s disease progression in Down syndrome

INTRODUCTION: Adults with Down syndrome (DS) are predisposed to Alzheimer’s disease (AD) and reveal early amyloid beta (Aβ) pathology in the brain. Positron emission tomography (PET) provides an in vivo measure of Aβ throughout the AD continuum. Due to the high prevalence of AD in DS, there is need...

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Veröffentlicht in:Neuroimage
Hauptverfasser: Zammit, Matthew D., Tudorascu, Dana L., Laymon, Charles M., Hartley, Sigan L., Zaman, Shahid H., Ances, Beau M., Johnson, Sterling C., Stone, Charles K., Mathis, Chester A., Klunk, William E., Cohen, Ann D., Handen, Benjamin L., Christian, Bradley T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953340/
https://ncbi.nlm.nih.gov/pubmed/33421595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2021.117728
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