PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer’s disease progression in Down syndrome

INTRODUCTION: Adults with Down syndrome (DS) are predisposed to Alzheimer’s disease (AD) and reveal early amyloid beta (Aβ) pathology in the brain. Positron emission tomography (PET) provides an in vivo measure of Aβ throughout the AD continuum. Due to the high prevalence of AD in DS, there is need...

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Bibliographic Details
Published in:Neuroimage
Main Authors: Zammit, Matthew D., Tudorascu, Dana L., Laymon, Charles M., Hartley, Sigan L., Zaman, Shahid H., Ances, Beau M., Johnson, Sterling C., Stone, Charles K., Mathis, Chester A., Klunk, William E., Cohen, Ann D., Handen, Benjamin L., Christian, Bradley T.
Format: Artigo
Language:Inglês
Published: 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953340/
https://ncbi.nlm.nih.gov/pubmed/33421595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2021.117728
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