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Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets
BRCA1 or BRCA2 inactivation drives hereditary breast and ovarian cancer, but also creates vulnerability to Parp inhibitors. To search for additional targets whose inhibition is synthetically lethal in BRCA2-deficient backgrounds, we screened two pairs of BRCA2 isogenic cell lines with DNA repair-foc...
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| Publicat a: | Mol Cell |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6892393/ https://ncbi.nlm.nih.gov/pubmed/30686591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.12.008 |
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