Synthetic lethality between CCNE1 amplification and loss of BRCA1

High-grade serous ovarian cancers (HGSCs) are characterized by a high frequency of TP53 mutations, BRCA1/2 inactivation, homologous recombination dysfunction, and widespread copy number changes. Cyclin E1 (CCNE1) gene amplification has been reported to occur independently of BRCA1/2 mutation, and it...

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Detalhes bibliográficos
Main Authors: Etemadmoghadam, Dariush, Weir, Barbara A., Au-Yeung, George, Alsop, Kathryn, Mitchell, Gillian, George, Joshy, Davis, Sally, D’Andrea, Alan D., Simpson, Kaylene, Hahn, William C., Bowtell, David D. L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845173/
https://ncbi.nlm.nih.gov/pubmed/24218601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314302110
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