Amplicon-Dependent CCNE1 Expression Is Critical for Clonogenic Survival after Cisplatin Treatment and Is Correlated with 20q11 Gain in Ovarian Cancer

Genomic amplification of 19q12 occurs in several cancer types including ovarian cancer where it is associated with primary treatment failure. We systematically attenuated expression of genes within the minimally defined 19q12 region in ovarian cell lines using short-interfering RNAs (siRNA) to ident...

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Detalhes bibliográficos
Main Authors: Etemadmoghadam, Dariush, George, Joshy, Cowin, Prue A., Cullinane, Carleen, Kansara, Maya, Gorringe, Kylie L., Smyth, Gordon K., Bowtell, David D. L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980490/
https://ncbi.nlm.nih.gov/pubmed/21103391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015498
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