Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations

Utilizing the concept of synthetic lethality has provided new opportunities for the development of targeted therapies, by allowing the targeting of loss of function genetic aberrations. In cancer cells with BRCA1 or BRCA2 loss of function, which harbor deficiency of DNA repair by homologous recombin...

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Detaylı Bibliyografya
Asıl Yazarlar: Dedes, Konstantin J, Wilkerson, Paul M, Wetterskog, Daniel, Weigelt, Britta, Ashworth, Alan, Reis-Filho, Jorge S
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Landes Bioscience 2011
Konular:
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Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117132/
https://ncbi.nlm.nih.gov/pubmed/21487248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.8.15273
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