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Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations
Utilizing the concept of synthetic lethality has provided new opportunities for the development of targeted therapies, by allowing the targeting of loss of function genetic aberrations. In cancer cells with BRCA1 or BRCA2 loss of function, which harbor deficiency of DNA repair by homologous recombin...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117132/ https://ncbi.nlm.nih.gov/pubmed/21487248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.8.15273 |
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