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BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability
BRCA1 plays a critical role in the regulation of homologous recombination (HR)-mediated DNA double-strand break repair. BRCA1-deficient cancers have evolved to tolerate loss of BRCA1 function. This renders them vulnerable to agents, such as PARP inhibitors, that are conditionally ‘synthetic lethal&#...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3030974/ https://ncbi.nlm.nih.gov/pubmed/21278454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjq055 |
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