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Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets
BRCA1 or BRCA2 inactivation drives hereditary breast and ovarian cancer, but also creates vulnerability to Parp inhibitors. To search for additional targets whose inhibition is synthetically lethal in BRCA2-deficient backgrounds, we screened two pairs of BRCA2 isogenic cell lines with DNA repair-foc...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6892393/ https://ncbi.nlm.nih.gov/pubmed/30686591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.12.008 |
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