Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α-synuclein mice

Parkinson’s disease (PD) is characterised pathologically by degeneration of the dopaminergic (DA) neurones of the substantia nigra pars compacta (SNpc) and the presence of α-synuclein containing Lewy body inclusions. Trichloroethylene (TCE) has been suggested as a potential environmental chemical th...

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Detalhes bibliográficos
Publicado no:Neurosci Lett
Main Authors: Keane, P.C., Hanson, P.S., Patterson, L., Blain, P.G., Hepplewhite, P., Khundakar, A.A., Judge, S.J., Kahle, P.J., LeBeau, F.E.N., Morris, C.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Scientific Publishers Ireland 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892271/
https://ncbi.nlm.nih.gov/pubmed/31422098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2019.134437
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