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Site-Selective C–H Halogenation Using Flavin-Dependent Halogenases Identified via Family-Wide Activity Profiling

[Image: see text] Enzymes are powerful catalysts for site-selective C–H bond functionalization. Identifying suitable enzymes for this task and for biocatalysis in general remains challenging, however, due to the fundamental difficulty of predicting catalytic activity from sequence information. In th...

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Библиографические подробности
Опубликовано в: :ACS Cent Sci
Главные авторы: Fisher, Brian F., Snodgrass, Harrison M., Jones, Krysten A., Andorfer, Mary C., Lewis, Jared C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2019
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891866/
https://ncbi.nlm.nih.gov/pubmed/31807686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.9b00835
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