Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways

Voltage-gated sodium channels (Na(V)s) are a key determinant of neuronal signalling. Neurotoxins from diverse taxa that selectively activate or inhibit Na(V) channels have helped unravel the role of Na(V) channels in diseases, including chronic pain. Spider venoms contain the most diverse array of i...

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Bibliografiske detaljer
Udgivet i:Toxins (Basel)
Main Authors: Dongol, Yashad, Cardoso, Fernanda C., Lewis, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891507/
https://ncbi.nlm.nih.gov/pubmed/31671792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins11110626
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