Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes

Gating modifier toxins (GMTs) are venom-derived peptides isolated from spiders and other venomous creatures and modulate activity of disease-relevant voltage-gated ion channels and are therefore being pursued as therapeutic leads. The amphipathic surface profile of GMTs has prompted the proposal tha...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Agwa, Akello J., Peigneur, Steve, Chow, Chun Yuen, Lawrence, Nicole, Craik, David J., Tytgat, Jan, King, Glenn F., Henriques, Sónia Troeira, Schroeder, Christina I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995520/
https://ncbi.nlm.nih.gov/pubmed/29703751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002553
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