Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry

The invasion of a suitable host hepatocyte by Plasmodium sporozoites is an essential step in malaria infection. We demonstrate that in infected hepatocytes, lysosomes are redistributed away from the nucleus, and surface exposure of lysosome-associated membrane protein 1 (LAMP1) is increased. Lysosom...

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Bibliografske podrobnosti
izdano v:iScience
Main Authors: Vijayan, Kamalakannan, Cestari, Igor, Mast, Fred D., Glennon, Elizabeth K.K., McDermott, Suzanne M., Kain, Heather S., Brokaw, Alyssa M., Aitchison, John D., Stuart, Kenneth, Kaushansky, Alexis
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889558/
https://ncbi.nlm.nih.gov/pubmed/31731198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.054
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