Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry

The invasion of a suitable host hepatocyte by Plasmodium sporozoites is an essential step in malaria infection. We demonstrate that in infected hepatocytes, lysosomes are redistributed away from the nucleus, and surface exposure of lysosome-associated membrane protein 1 (LAMP1) is increased. Lysosom...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Vijayan, Kamalakannan, Cestari, Igor, Mast, Fred D., Glennon, Elizabeth K.K., McDermott, Suzanne M., Kain, Heather S., Brokaw, Alyssa M., Aitchison, John D., Stuart, Kenneth, Kaushansky, Alexis
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889558/
https://ncbi.nlm.nih.gov/pubmed/31731198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.054
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