Učitavanje...
Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis
We have recently shown that hydrophobic weak base anticancer drugs are highly sequestered in acidic lysosomes, inducing TFEB-mediated lysosomal biogenesis and markedly increased lysosome numbers per cell. This enhanced lysosomal sequestration of chemotherapeutics, away from their intracellular targe...
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| Izdano u: | Oncotarget |
|---|---|
| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Impact Journals LLC
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5542171/ https://ncbi.nlm.nih.gov/pubmed/28187461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15155 |
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