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Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis
We have recently shown that hydrophobic weak base anticancer drugs are highly sequestered in acidic lysosomes, inducing TFEB-mediated lysosomal biogenesis and markedly increased lysosome numbers per cell. This enhanced lysosomal sequestration of chemotherapeutics, away from their intracellular targe...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5542171/ https://ncbi.nlm.nih.gov/pubmed/28187461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15155 |
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