PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-Catenin(Y654)

BACKGROUND & AIMS: Identification and validation of new functionally relevant and pharmacologically actionable targets for pancreatic ductal adenocarcinoma (PDAC) remains a great challenge. Premalignant acinar cell reprogramming (acinar-to-ductal metaplasia [ADM]) is a precursor of pancreatic in...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Gao, Chenxi, Chen, Guangming, Zhang, Dennis Han, Zhang, Judy, Kuan, Shih-Fan, Hu, Wenhuo, Esni, Farzad, Gao, Xuan, Guan, Jun-Lin, Chu, Edward, Hu, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889497/
https://ncbi.nlm.nih.gov/pubmed/31330317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.07.004
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