MEK nuclear localization promotes YAP stability via sequestering β-TrCP in KRAS mutant cancer cells

Tumours manage to survive the ablation of mutant KRAS, despite the development of KRAS-targeted drugs. Here we describe that inhibition of mutant KRAS promotes MEK nuclear localization as an alternative mechanism of KRAS-targeted drugs resistance. Tissue microarray analysis in colon tumours shows th...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Xu, Huanji, Zhou, Sheng, Xia, Hongwei, Yu, Huangfei, Tang, Qiulin, Bi, Feng
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889282/
https://ncbi.nlm.nih.gov/pubmed/30833665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0309-6
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