DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice

DNA methylation regulates cell type-specific gene expression. Here, in a transgenic mouse model, we show that deletion of the gene encoding DNA methyltransferase Dnmt3a in hypothalamic AgRP neurons causes a sedentary phenotype characterized by reduced voluntary exercise and increased adiposity. Whol...

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Publicat a:Nat Commun
Autors principals: MacKay, Harry, Scott, C. Anthony, Duryea, Jack D., Baker, Maria S., Laritsky, Eleonora, Elson, Amanda E., Garland Jr., Theodore, Fiorotto, Marta L., Chen, Rui, Li, Yumei, Coarfa, Cristian, Simerly, Richard B., Waterland, Robert A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889160/
https://ncbi.nlm.nih.gov/pubmed/31792207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13339-3
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