Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis

Prostate cancer (PCa) metastasizes selectively to bone through unknown mechanisms. In the current study, we identified exosome-mediated transfer of pyruvate kinase M2 (PKM2) from PCa cells into bone marrow stromal cells (BMSCs) as a novel mechanism through which primary tumor-derived exosomes promot...

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Vydáno v:J Exp Med
Hlavní autoři: Dai, Jinlu, Escara-Wilke, June, Keller, Jill M., Jung, Younghun, Taichman, Russell S., Pienta, Kenneth J., Keller, Evan T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888980/
https://ncbi.nlm.nih.gov/pubmed/31548301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190158
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