Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis

Prostate cancer (PCa) metastasizes selectively to bone through unknown mechanisms. In the current study, we identified exosome-mediated transfer of pyruvate kinase M2 (PKM2) from PCa cells into bone marrow stromal cells (BMSCs) as a novel mechanism through which primary tumor-derived exosomes promot...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Dai, Jinlu, Escara-Wilke, June, Keller, Jill M., Jung, Younghun, Taichman, Russell S., Pienta, Kenneth J., Keller, Evan T.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888980/
https://ncbi.nlm.nih.gov/pubmed/31548301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190158
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados