Improved Tumor Purity Metrics in Next-generation Sequencing for Clinical Practice: The Integrated Interpretation of Neoplastic Cellularity and Sequencing Results (IINCaSe) Approach

Neoplastic cellularity contributes to the analytic sensitivity of most present technologies for mutation detection, such that they underperform when stroma and inflammatory cells dilute a cancer specimen’s variant fraction. Thus, tumor purity assessment by light microscopy is used to determine sampl...

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Detaylı Bibliyografya
Yayımlandı:Appl Immunohistochem Mol Morphol
Asıl Yazarlar: Patel, Nirali M., Jo, Heejoon, Eberhard, David A., Yin, Xiaoying, Hayward, Michele C., Stein, Matthew K., Hayes, David Neil, Grilley-Olson, Juneko E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Lippincott Williams & Wilkins 2019
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887630/
https://ncbi.nlm.nih.gov/pubmed/30102605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAI.0000000000000684
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