Targeted Next Generation Sequencing Identifies Clinically Actionable Mutations in Patients with Melanoma

Somatic sequencing of cancers has produced new insight into tumorigenesis, tumor heterogeneity, and disease progression, but the vast majority of genetic events identified are of indeterminate clinical significance. Here we describe a NextGen sequencing approach to fully analyze 248 genes, including...

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Detalhes bibliográficos
Main Authors: Jeck, William R., Parker, Joel, Carson, Craig C., Shields, Janiel M., Sambade, Maria J., Peters, Eldon C., Burd, Christin E., Thomas, Nancy E., Chiang, Derek Y., Liu, Wenjin, Eberhard, David A., Ollila, David, Grilley-Olson, Juneko, Moschos, Stergios, Hayes, D. Neil, Sharpless, Norman E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121659/
https://ncbi.nlm.nih.gov/pubmed/24628946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12238
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