Targeted Next Generation Sequencing Identifies Clinically Actionable Mutations in Patients with Melanoma

Somatic sequencing of cancers has produced new insight into tumorigenesis, tumor heterogeneity, and disease progression, but the vast majority of genetic events identified are of indeterminate clinical significance. Here we describe a NextGen sequencing approach to fully analyze 248 genes, including...

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Bibliografiske detaljer
Main Authors: Jeck, William R., Parker, Joel, Carson, Craig C., Shields, Janiel M., Sambade, Maria J., Peters, Eldon C., Burd, Christin E., Thomas, Nancy E., Chiang, Derek Y., Liu, Wenjin, Eberhard, David A., Ollila, David, Grilley-Olson, Juneko, Moschos, Stergios, Hayes, D. Neil, Sharpless, Norman E.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121659/
https://ncbi.nlm.nih.gov/pubmed/24628946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12238
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