Improved Tumor Purity Metrics in Next-generation Sequencing for Clinical Practice: The Integrated Interpretation of Neoplastic Cellularity and Sequencing Results (IINCaSe) Approach

Neoplastic cellularity contributes to the analytic sensitivity of most present technologies for mutation detection, such that they underperform when stroma and inflammatory cells dilute a cancer specimen’s variant fraction. Thus, tumor purity assessment by light microscopy is used to determine sampl...

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Bibliografiske detaljer
Udgivet i:Appl Immunohistochem Mol Morphol
Main Authors: Patel, Nirali M., Jo, Heejoon, Eberhard, David A., Yin, Xiaoying, Hayward, Michele C., Stein, Matthew K., Hayes, David Neil, Grilley-Olson, Juneko E.
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2019
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887630/
https://ncbi.nlm.nih.gov/pubmed/30102605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAI.0000000000000684
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