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Improved Tumor Purity Metrics in Next-generation Sequencing for Clinical Practice: The Integrated Interpretation of Neoplastic Cellularity and Sequencing Results (IINCaSe) Approach
Neoplastic cellularity contributes to the analytic sensitivity of most present technologies for mutation detection, such that they underperform when stroma and inflammatory cells dilute a cancer specimen’s variant fraction. Thus, tumor purity assessment by light microscopy is used to determine sampl...
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| Опубликовано в: : | Appl Immunohistochem Mol Morphol |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Lippincott Williams & Wilkins
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6887630/ https://ncbi.nlm.nih.gov/pubmed/30102605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAI.0000000000000684 |
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