Improved Tumor Purity Metrics in Next-generation Sequencing for Clinical Practice: The Integrated Interpretation of Neoplastic Cellularity and Sequencing Results (IINCaSe) Approach

Neoplastic cellularity contributes to the analytic sensitivity of most present technologies for mutation detection, such that they underperform when stroma and inflammatory cells dilute a cancer specimen’s variant fraction. Thus, tumor purity assessment by light microscopy is used to determine sampl...

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Detalhes bibliográficos
Publicado no:Appl Immunohistochem Mol Morphol
Main Authors: Patel, Nirali M., Jo, Heejoon, Eberhard, David A., Yin, Xiaoying, Hayward, Michele C., Stein, Matthew K., Hayes, David Neil, Grilley-Olson, Juneko E.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887630/
https://ncbi.nlm.nih.gov/pubmed/30102605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAI.0000000000000684
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