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Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM
In preparation for bidirectional replication, the origin recognition complex (ORC) loads two MCM helicases forming a head-to-head double hexamer (DH) around DNA(1,2). How DH formation occurs is debated. Single-molecule experiments suggest a sequential mechanism whereby ORC-dependent loading of the f...
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| 發表在: | Nature |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6887548/ https://ncbi.nlm.nih.gov/pubmed/31748745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1768-0 |
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