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A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding
Licensing of eukaryotic origins of replication requires DNA loading of two copies of the Mcm2-7 replicative helicase to form a head-to-head double-hexamer, ensuring activated helicases depart the origin bidirectionally. To understand the formation and importance of this double-hexamer, we identified...
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| I publikationen: | eLife |
|---|---|
| Huvudupphovsmän: | , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
eLife Sciences Publications, Ltd
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6701924/ https://ncbi.nlm.nih.gov/pubmed/31385807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.45538 |
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