Cardiac glycosides are broad-spectrum senolytics

Senescence is a cellular stress response that results in the stable arrest of old, damaged or preneoplastic cells. Oncogene-induced senescence is tumor suppressive but can also exacerbate tumorigenesis through the secretion of pro-inflammatory factors from senescent cells. Drugs that selectively kil...

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Detalhes bibliográficos
Publicado no:Nat Metab
Main Authors: Guerrero, Ana, Herranz, Nicolás, Sun, Bin, Wagner, Verena, Gallage, Suchira, Guiho, Romain, Wolter, Katharina, Pombo, Joaquim, Irvine, Elaine E., Innes, Andrew J., Birch, Jodie, Glegola, Justyna, Manshaei, Saba, Heide, Danijela, Dharmalingam, Gopuraja, Harbig, Jule, Olona, Antoni, Behmoaras, Jacques, Dauch, Daniel, Uren, Anthony G., Zender, Lars, Vernia, Santiago, Martínez-Barbera, Juan Pedro, Heikenwalder, Mathias, Withers, Dominic J., Gil, Jesús
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887543/
https://ncbi.nlm.nih.gov/pubmed/31799499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0122-z
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