Cardiac glycosides are broad-spectrum senolytics

Senescence is a cellular stress response that results in the stable arrest of old, damaged or preneoplastic cells. Oncogene-induced senescence is tumor suppressive but can also exacerbate tumorigenesis through the secretion of pro-inflammatory factors from senescent cells. Drugs that selectively kil...

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Publicado en:Nat Metab
Autores principales: Guerrero, Ana, Herranz, Nicolás, Sun, Bin, Wagner, Verena, Gallage, Suchira, Guiho, Romain, Wolter, Katharina, Pombo, Joaquim, Irvine, Elaine E., Innes, Andrew J., Birch, Jodie, Glegola, Justyna, Manshaei, Saba, Heide, Danijela, Dharmalingam, Gopuraja, Harbig, Jule, Olona, Antoni, Behmoaras, Jacques, Dauch, Daniel, Uren, Anthony G., Zender, Lars, Vernia, Santiago, Martínez-Barbera, Juan Pedro, Heikenwalder, Mathias, Withers, Dominic J., Gil, Jesús
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887543/
https://ncbi.nlm.nih.gov/pubmed/31799499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0122-z
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