Wird geladen...

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Oncogene-induced senescence is a potent tumor-suppressive response. Paradoxically, senescence also induces an inflammatory secretome that promotes carcinogenesis and age-related pathologies. Consequently, the senescence-associated secretory phenotype (SASP) is a potential therapeutic target. Here, w...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer Cell
Hauptverfasser: Georgilis, Athena, Klotz, Sabrina, Hanley, Christopher J., Herranz, Nicolas, Weirich, Benedikt, Morancho, Beatriz, Leote, Ana Carolina, D'Artista, Luana, Gallage, Suchira, Seehawer, Marco, Carroll, Thomas, Dharmalingam, Gopuraja, Wee, Keng Boon, Mellone, Marco, Pombo, Joaquim, Heide, Danijela, Guccione, Ernesto, Arribas, Joaquín, Barbosa-Morais, Nuno L., Heikenwalder, Mathias, Thomas, Gareth J., Zender, Lars, Gil, Jesús
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048363/
https://ncbi.nlm.nih.gov/pubmed/29990503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.06.007
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!