Significant alteration of liver metabolites by AAV8.Urocortin 2 gene transfer in mice with insulin resistance

INTRODUCTION: Urocortin 2 (Ucn2) is a 38-amino acid peptide of the corticotropin-releasing factor family. Intravenous (IV) delivery of an adeno-associated virus vector serotype 8 encoding Ucn2 (AAV8.Ucn2) increases insulin sensitivity and glucose disposal in mice with insulin resistance. OBJECTIVE:...

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Bibliographic Details
Published in:PLoS One
Main Authors: Kim, Young Chul, Truax, Agnieszka D., Giamouridis, Dimosthenis, Lai, N. Chin, Guo, Tracy, Hammond, H. Kirk, Gao, Mei Hua
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886859/
https://ncbi.nlm.nih.gov/pubmed/31790421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0224428
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