Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice

Urocortin-2 (UCn2) peptide infusion increases cardiac function in patients with heart failure, but chronic peptide infusion is cumbersome, is costly, and provides only short-term benefits. Gene transfer would circumvent these shortcomings. We previously showed that a single intravenous (IV) injectio...

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Vydáno v:Hum Gene Ther
Hlavní autoři: Lai, N. Chin, Gao, Mei Hua, Giamouridis, Dimosthenis, Suarez, Jorge, Miyanohara, Atsushi, Parikh, Jay, Hightower, Stephen, Guo, Tracy, Dillmann, Wolfgang, Kim, Young-Chul, Diaz-Juarez, Julieta, Hammond, H. Kirk
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492611/
https://ncbi.nlm.nih.gov/pubmed/25760560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2014.157
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