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Intravenous Adeno-Associated Virus Serotype 8 Encoding Urocortin-2 Provides Sustained Augmentation of Left Ventricular Function in Mice

Urocortin-2 (UCn2) peptide infusion increases cardiac function in patients with heart failure, but chronic peptide infusion is cumbersome, costly, and provides only short-term benefits. Gene transfer would circumvent these shortcomings. Here we ask whether a single intravenous injection of adeno-ass...

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Autors principals: Gao, Mei Hua, Lai, N. Chin, Miyanohara, Atsushi, Schilling, Jan M., Suarez, Jorge, Tang, Tong, Guo, Tracy, Tang, Ruoying, Parikh, Jay, Giamouridis, Dimosthenis, Dillmann, Wolfgang H., Patel, Hemal H., Roth, David M., Dalton, Nancy D., Hammond, H. Kirk
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3768340/
https://ncbi.nlm.nih.gov/pubmed/23931341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.088
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