Intravenous Adeno-Associated Virus Serotype 8 Encoding Urocortin-2 Provides Sustained Augmentation of Left Ventricular Function in Mice

Urocortin-2 (UCn2) peptide infusion increases cardiac function in patients with heart failure, but chronic peptide infusion is cumbersome, costly, and provides only short-term benefits. Gene transfer would circumvent these shortcomings. Here we ask whether a single intravenous injection of adeno-ass...

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Detalhes bibliográficos
Main Authors: Gao, Mei Hua, Lai, N. Chin, Miyanohara, Atsushi, Schilling, Jan M., Suarez, Jorge, Tang, Tong, Guo, Tracy, Tang, Ruoying, Parikh, Jay, Giamouridis, Dimosthenis, Dillmann, Wolfgang H., Patel, Hemal H., Roth, David M., Dalton, Nancy D., Hammond, H. Kirk
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3768340/
https://ncbi.nlm.nih.gov/pubmed/23931341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.088
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