One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance

Using mice rendered insulin resistant with high fat diets (HFD), we examined blood glucose levels and insulin resistance after i.v. delivery of an adeno-associated virus type 8 encoding murine urocortin 2 (AAV8.UCn2). A single i.v. injection of AAV8.UCn2-normalized blood glucose and glucose disposal...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Gao, Mei Hua, Giamouridis, Dimosthenis, Lai, N. Chin, Walenta, Evelyn, Paschoal, Vivian Almeida, Kim, Young Chul, Miyanohara, Atsushi, Guo, Tracy, Liao, Min, Liu, Li, Tan, Zhen, Ciaraldi, Theodore P., Schenk, Simon, Bhargava, Aditi, Oh, Da Young, Hammond, H. Kirk
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033760/
https://ncbi.nlm.nih.gov/pubmed/27699250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88322
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