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Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation
Some of the most widely used drugs, like aspirin and penicillin, are covalent drugs. Covalent binding can improve potency, selectivity and duration of the effects, but the intrinsic reactivity represents a potential liability and may result in idiosyncratic toxicity. For decades, the cons were belie...
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| Publicado no: | Cell Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6886688/ https://ncbi.nlm.nih.gov/pubmed/31631011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.09.012 |
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