Leptin Restores Endothelial Function via Endothelial PPARγ-Nox1-Mediated Mechanisms in a Mouse Model of Congenital Generalized Lipodystrophy

Leptin is the current treatment for metabolic disorders associated with acquired and congenital generalized lipodystrophy (CGL). Although excess leptin levels have been associated with vascular inflammation and cardiovascular disease in the context of obesity, the effects of chronic leptin treatment...

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Publicado no:Hypertension
Main Authors: Bruder-Nascimento, Thiago, Faulkner, Jessica L., Haigh, Stephen, Kennard, Simone, Antonova, Galina, Patel, Vijay S., Fulton, David J.R., Chen, Weiqin, de Chantemèle, Eric J. Belin
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886673/
https://ncbi.nlm.nih.gov/pubmed/31656096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.119.13398
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