Co-occurrence of analogous enzymes determines evolution of a novel (βα)(8)-isomerase sub-family after non-conserved mutations in flexible loop

We investigate the evolution of co-occurring analogous enzymes involved in l-tryptophan and l-histidine biosynthesis in Actinobacteria. Phylogenetic analysis of trpF homologues, a missing gene in certain clades of this lineage whose absence is complemented by a dual-substrate HisA homologue, termed...

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Bibliografiska uppgifter
I publikationen:Biochem J
Huvudupphovsmän: Verduzco-Castro, Ernesto A., Michalska, Karolina, Endres, Michael, Juárez-Vazquez, Ana L., Noda-García, Lianet, Chang, Changsoo, Henry, Christopher S., Babnigg, Gyorgy, Joachimiak, Andrzej, Barona-Gόmez, Francisco
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886522/
https://ncbi.nlm.nih.gov/pubmed/26929404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20151271
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