Evolution of substrate specificity in a retained enzyme driven by gene loss

The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics and metabolic modeling to detect bacterial species that are evolving by gene loss, with the finding that Actinomycetaceae genomes from human cavities are undergoing...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Juárez-Vázquez, Ana Lilia, Edirisinghe, Janaka N, Verduzco-Castro, Ernesto A, Michalska, Karolina, Wu, Chenggang, Noda-García, Lianet, Babnigg, Gyorgy, Endres, Michael, Medina-Ruíz, Sofía, Santoyo-Flores, Julián, Carrillo-Tripp, Mauricio, Ton-That, Hung, Joachimiak, Andrzej, Henry, Christopher S, Barona-Gómez, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404923/
https://ncbi.nlm.nih.gov/pubmed/28362260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22679
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