Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood

Apoptosis is a recognized limitation to generating large numbers of megakaryocytes in culture. The genes responsible have been rigorously studied in vivo in mice, but are poorly characterized in human culture systems. As CD34-positive ((+)) cells isolated from human umbilical vein cord blood were di...

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Pubblicato in:Haematologica
Autori principali: Bhatlekar, Seema, Basak, Indranil, Edelstein, Leonard C., Campbell, Robert A., Lindsey, Cory R., Italiano, Joseph E., Weyrich, Andrew S., Rowley, Jesse W., Rondina, Matthew T., Sola-Visner, Martha, Bray, Paul F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886406/
https://ncbi.nlm.nih.gov/pubmed/30733267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.204685
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