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Pharmacological and Molecular Mechanisms Behind the Sterilizing Activity of Pyrazinamide
Inclusion of pyrazinamide in the tuberculosis drug regimen in the 1970s allowed reduction of treatment duration from 12 to 6 months. Pyrazinamide has this remarkable effect in patients despite displaying poor potency against Mycobacterium tuberculosis in vitro. The pharmacological basis for the drug...
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| Опубликовано в: : | Trends Pharmacol Sci |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6884696/ https://ncbi.nlm.nih.gov/pubmed/31704175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2019.10.005 |
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