Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc(1) and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis.

Cytochrome bc(1) inhibitors have been broadly studied as human and veterinary medicines, and agricultural fungicides. For the most part, cytochrome bc(1) inhibitors compete with ubiquinol at the ubiquinol oxidation (Qo) site or with ubiquinone at the quinone reduction (Qi) site. 4(1H)-Quinolones wit...

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Détails bibliographiques
Publié dans:ACS Infect Dis
Auteurs principaux: McConnell, Erin V., Bruzual, Igor, Pou, Sovitj, Winter, Rolf, Dodean, Rozalia A., Smilkstein, Martin J., Krollenbrock, Alina, Nilsen, Aaron, Zakharov, Lev N., Riscoe, Michael K., Doggett, J. Stone
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884402/
https://ncbi.nlm.nih.gov/pubmed/30117728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00133
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