Transient stabilization, rather than inhibition of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma

Therapeutic targeting of initiating oncogenes is the mainstay of precision medicine. Considerable efforts have been expended toward silencing MYC, which drives many human cancers including Burkitt lymphomas (BL). Yet, the effects of MYC silencing on standard-of-care therapies are poorly understood....

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Pubblicato in:Leukemia
Autori principali: Harrington, Colleen T., Sotillo, Elena, Robert, Aude, Hayer, Katharina E., Bogusz, Agata M., Psathas, James, Yu, Duonan, Taylor, Deanne, Dang, Chi V., Klein, Peter, Hogarty, Michael D., Geoerger, Birgit, El-Deiry, Wafik S., Wiels, Joëlle, Thomas-Tikhonenko, Andrei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884148/
https://ncbi.nlm.nih.gov/pubmed/30914792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0454-4
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