Transient stabilization, rather than inhibition of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma

Therapeutic targeting of initiating oncogenes is the mainstay of precision medicine. Considerable efforts have been expended toward silencing MYC, which drives many human cancers including Burkitt lymphomas (BL). Yet, the effects of MYC silencing on standard-of-care therapies are poorly understood....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Leukemia
Egile Nagusiak: Harrington, Colleen T., Sotillo, Elena, Robert, Aude, Hayer, Katharina E., Bogusz, Agata M., Psathas, James, Yu, Duonan, Taylor, Deanne, Dang, Chi V., Klein, Peter, Hogarty, Michael D., Geoerger, Birgit, El-Deiry, Wafik S., Wiels, Joëlle, Thomas-Tikhonenko, Andrei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884148/
https://ncbi.nlm.nih.gov/pubmed/30914792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0454-4
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