Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1

p53 is the most frequently mutated gene in human cancers and mutant p53 has a gain of function (GOF) that promotes tumor progression and therapeutic resistance. One of the major GOF activities of mutant p53 is to suppress 2 other p53 family proteins, p63 and p73. However, the molecular basis is not...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Zhang, Jin, Sun, Wenqiang, Kong, Xiangmudong, Zhang, Yanhong, Yang, Hee Jung, Ren, Cong, Jiang, Yuqian, Chen, Mingyi, Chen, Xinbin
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883818/
https://ncbi.nlm.nih.gov/pubmed/31712410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913919116
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