MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment

BACKGROUND: Programmed death-1 (PD-1) immune checkpoint blockade has achieved clinical successes in cancer therapy. However, the response rate of anti-PD-1 agents remains low. Additionally, a subpopulation of patients developed hyperprogressive disease upon PD-1 blockade therapy. Combination therapy...

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Gepubliceerd in:J Immunother Cancer
Hoofdauteurs: Fang, Douglas D., Tang, Qiuqiong, Kong, Yanhui, Wang, Qixin, Gu, Jiaxing, Fang, Xu, Zou, Peng, Rong, Tao, Wang, Jingwen, Yang, Dajun, Zhai, Yifan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883539/
https://ncbi.nlm.nih.gov/pubmed/31779710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0750-6
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