Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity

Although immunotherapy by PD-1 blockade has dramatically improved the survival rate of cancer patients, further improvement in efficacy is required to reduce the fraction of less sensitive patients. In mouse models of PD-1 blockade therapy, we found that tumor-reactive cytotoxic T lymphocytes (CTLs)...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Chamoto, Kenji, Chowdhury, Partha S., Kumar, Alok, Sonomura, Kazuhiro, Matsuda, Fumihiko, Fagarasan, Sidonia, Honjo, Tasuku
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293087/
https://ncbi.nlm.nih.gov/pubmed/28096382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620433114
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