Circulation of gut-preactivated naïve CD8(+) T cells enhances antitumor immunity in B cell-defective mice

The gut microbiome has garnered attention as an effective target to boost immunity and improve cancer immunotherapy. We found that B cell-defective (BCD) mice, such as µ-membrane targeted deletion (µMT) and activation-induced cytidine deaminase (AID) knockouts (KOs), have elevated antitumor immunity...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Akrami, Maryam, Menzies, Rosemary, Chamoto, Kenji, Miyajima, Michio, Suzuki, Ryuji, Sato, Hiroyuki, Nishii, Akiko, Tomura, Michio, Fagarasan, Sidonia, Honjo, Tasuku
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2020
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519229/
https://ncbi.nlm.nih.gov/pubmed/32907933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010981117
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