Circulation of gut-preactivated naïve CD8(+) T cells enhances antitumor immunity in B cell-defective mice

The gut microbiome has garnered attention as an effective target to boost immunity and improve cancer immunotherapy. We found that B cell-defective (BCD) mice, such as µ-membrane targeted deletion (µMT) and activation-induced cytidine deaminase (AID) knockouts (KOs), have elevated antitumor immunity...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Akrami, Maryam, Menzies, Rosemary, Chamoto, Kenji, Miyajima, Michio, Suzuki, Ryuji, Sato, Hiroyuki, Nishii, Akiko, Tomura, Michio, Fagarasan, Sidonia, Honjo, Tasuku
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519229/
https://ncbi.nlm.nih.gov/pubmed/32907933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010981117
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