Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells

Dedifferentiated papillary thyroid cancer (DePTC) is characterized by aggressive growth, recurrence, distant metastasis, and resistance to radioactive iodine (RAI) therapy. DePTC is also accompanied by poor prognosis and high early-mortality. Nevertheless, most DePTC cells show intact p53 downstream...

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Pubblicato in:Oncotarget
Autori principali: Chen, Haibo, Luo, Dingyuan, Zhang, Lin, Lin, Xiaofeng, Luo, Qiuyun, Yi, Hanjie, Wang, Jing, Yan, Xianglei, Li, Baoxia, Chen, Yuelei, Liu, Xingguang, Zhang, Hong, Liu, Sheng, Qiu, Miaozhen, Yang, Dajun, Jiang, Ningyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522123/
https://ncbi.nlm.nih.gov/pubmed/28498808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17398
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