Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells

Dedifferentiated papillary thyroid cancer (DePTC) is characterized by aggressive growth, recurrence, distant metastasis, and resistance to radioactive iodine (RAI) therapy. DePTC is also accompanied by poor prognosis and high early-mortality. Nevertheless, most DePTC cells show intact p53 downstream...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Chen, Haibo, Luo, Dingyuan, Zhang, Lin, Lin, Xiaofeng, Luo, Qiuyun, Yi, Hanjie, Wang, Jing, Yan, Xianglei, Li, Baoxia, Chen, Yuelei, Liu, Xingguang, Zhang, Hong, Liu, Sheng, Qiu, Miaozhen, Yang, Dajun, Jiang, Ningyi
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522123/
https://ncbi.nlm.nih.gov/pubmed/28498808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17398
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