A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma

BACKGROUND: Gastric cancer is the leading cause of cancer related death worldwide. Radiation alone or combined with chemotherapy plays important role in locally advanced and metastatic gastric adenocarcinoma. MDM2–p53 interaction and downstream signaling affect cellular response to DNA damage which...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Yi, Hanjie, Yan, Xianglei, Luo, Qiuyun, Yuan, Luping, Li, Baoxia, Pan, Wentao, Zhang, Lin, Chen, Haibo, Wang, Jing, Zhang, Yubin, Zhai, Yifan, Qiu, Miao-Zhen, Yang, Da-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930807/
https://ncbi.nlm.nih.gov/pubmed/29716622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0765-8
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