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Redox-sensitive lipophilic prodrugs: delivering unstable chemotherapeutant for improved cancer therapy
Therapeutic application of unmodified camptothecin (CPT) is severely restricted by its extremely low water solubility and the instability of active lactone ring. In this study, a redox-sensitive CPT-OA conjugate containing the disulfide bond (CPT-SS-OA) was used to deliver the lactone-stabilized CPT...
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| Publicado no: | Drug Deliv |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6882494/ https://ncbi.nlm.nih.gov/pubmed/31735094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2019.1678696 |
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